Personally, I have not had any experiences troubleshooting or even seen a 4k drive yet. But there are even chatter out there and I thought I would just put a few links here regarding 4k drives and how it will impact Windows support for my future references:
- The Facts: 4K Advanced Format Hard Disks
- Information about Microsoft support policy for large sector drives in Windows
- NTFS And 4K Disks
Salt * Wet * Bytes 